Study of electrochemical behavior of two chemically similar acridines: Tacrine and 9-aminoacridine on hanging mercury drop electrode

ABSTRACT. The electrochemical behavior of two chemically related acridine compounds: tacrine (TAC) and 9-aminoacridine (9-AA) was investigated on a hanging mercury drop electrode (HDME). study carried out by using Osteryoung square wave voltammetry (OSWV) cyclic (CV) techniques in the Britton-Robinson (B-R) buffer solution at pH = 2.0–12.0, KCl (0.1/0.2/0.3 M) methanol (0.0-50%) mixture as supporting electrolyte. TAC showed maximum current 7.5 while 9-AA 10, (0.3M), 10% methanol. reduction HDME CV resulted quasi-reversibility, mainly diffusion-controlled reaction. reaction involved 1e–/1H+ nitrogen atom case second process 2e–/2H+ intra-cyclic azomethine group. peak potential structurally compounds is influenced values percentage organic solvent electrolytes. Also, may provide insight into electron transfer pathways biological reactions acridines their electrode.
 
 KEY WORDS: Tacrine, 9-Aminoacridine, Cyclic voltammetry, Hanging dropping electrode
 Bull. Chem. Soc. Ethiop. 2021, 35(3), 639-646.
 DOI: https://dx.doi.org/10.4314/bcse.v35i3.14